Reproductive physiology of the boar: what defines the potential fertility of an ejaculate?

Rodríguez Martínez, Heriberto; Martínez Serrano, Cristina A.; Álvarez Rodríguez, Manuel; Martínez, Emilio A.; Roca, Jordi

Publication:
Reproductive physiology of the boar: what defines the potential fertility of an ejaculate?

dc.contributor.author	Rodríguez Martínez, Heriberto
dc.contributor.author	Martínez Serrano, Cristina A.
dc.contributor.author	Álvarez Rodríguez, Manuel
dc.contributor.author	Martínez, Emilio A.
dc.contributor.author	Roca, Jordi
dc.contributor.department	Medicina y Cirugía Animal
dc.date.accessioned	2024-09-05T09:51:25Z
dc.date.available	2024-09-05T09:51:25Z
dc.date.issued	2024-04-18
dc.description	© 2024 The Author(s). This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by4.0/. This document is the Accepted version of a Published Work that appeared in final form in Animal Reproduction Science. To access the final edited and published work see https://doi.org/10.1016/j.anireprosci.2024.107476
dc.description.abstract	Despite decades of research and handling of semen for use in artificial insemination (AI) and other assisted reproductive technologies, 5-10% of selected boar sires are still considered sub-fertile, escaping current assessment methods for sperm quality and resilience to preservation. As end-product, the ejaculate (emitted spermatozoa sequentially exposed to the composite seminal plasma, the SP) ought to define the homeostasis of the testes, the epididymis, and the accessory sexual glands. Yet, linking findings in the ejaculate to sperm production biology and fertility is suboptimal. The present essay critically reviews how the ejaculate of a fertile boar can help us to diagnose both reproductive health and resilience to semen handling, focusing on methods -available and under development- to identify suitable biomarkers for cryotolerance and fertility. Bulk SP, semen proteins and microRNAs (miRNAs) have, albeit linked to sperm function and fertility after AI, failed to enhance reproductive outcomes at commercial level, perhaps for just being components of a complex functional pathway. Hence, focus is now on the interaction sperm-SP, comparing in vivo with ex vivo, and regarding nano-sized lipid bilayer seminal extracellular vesicles (sEVs) as priority. sEVs transport fragile molecules (lipids, proteins, nucleic acids) which, shielded from degradation, mediate cell-to-cell communication with spermatozoa and the female internal genital tract. Such interaction modulates essential reproductive processes, from sperm homeostasis to immunological female tolerance. sEVs can be harvested, characterized, stored, and manipulated, e.g. can be used for andrological diagnosis, selection of breeders, and alternatively be used as additives to improve cryosurvival and fertility.	es
dc.format	application/pdf	es
dc.format.extent	18	es
dc.identifier.citation	Anim Reprod Sci :107476
dc.identifier.doi	https://doi.org/10.1016/j.anireprosci.2024.107476
dc.identifier.issn	Print: 0378-4320
dc.identifier.issn	Electronic: 1873-2232
dc.identifier.uri	http://hdl.handle.net/10201/143620
dc.language	eng	es
dc.publisher	Elsevier
dc.relation	The research of the authors was funded by the Research Council FORMAS, Stockholm (Grant 2019-00288), the Spanish Ministry of Science and Innovation, Madrid, Spain (MCIN/AEI/10.13039/501100011033): grants PID2020-113493RB-I00; PID2019-108320RJI00; RYC2020-028615-I; PID2022-136561OB-I00; and PID2022-137645OB-I00, FEDER funds (EU), and grant 21935/PI/22 of the Seneca Foundation, Murcia, Spain.	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0378432024000678?via%3Dihub	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Sperm production	es
dc.subject	Maturation
dc.subject	Ejaculate
dc.subject	Diagnostics
dc.subject	Fertility biomarkers
dc.subject	Pig
dc.title	Reproductive physiology of the boar: what defines the potential fertility of an ejaculate?	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es