Publication: Postnatal morphologic changes and glial fibrillary acidic
protein immunoreactivity in the anteroventral cochlear
nucleus of the acoustically-deprived gerbil
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Date
1997
Authors
Yu, S. M. ; Du, S.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study investigated the morphological
changes and glial fibrillary acidic protein immunoreactivity
(GFAP-IR) in the anteroventral cochlear
nucleus (AVCN) of acoustically-deprived gerbils during
postnatal development. The mongolian gerbil, Meriones
unguiculatus, had been acoustically deprived on the right
side or left side by a surgical ligation of the external
auditory canal at postnatal day 12-14. No discernible
microcysts were located in the ipsilateral AVCN at one,
three, six and nine months after monaural ligation. Also,
no discernible microcysts were located in the contralateral
AVCN at one and three months after monaural
ligation. Numerous microcysts were located in the
contralateral AVCN at six months after monaural
ligation and were slightly reduced in number at nine
months after monaural ligation. Some of the microcysts
closely apposed to and connected with the blood vessels
through a leakage route or channel. A foamy region was
found in the superficial granule cell cap of the AVCN.
The foamy region became evident in the ipsilateral
AVCN at three months after monaural ligation. However,
the foamy region became evident in the contralateral
AVCN at three and nine months after monaural ligation.
Vacuoles were mainly found in the neuronal cells at the
junction of the superficial and deep layers in the AVCN.
These vacuoles were found in the contralateral AVCN at
one, three, six, and nine months after monaural ligation.
However, vacuoles were found in the ipsilateral AVCN
only at three months after monaural ligation.
Morphological changes of the myelin sheath were found
to be more severe in the contralateral AVCN than in the
ipsilateral. GFAP-IR was located in the superficial layer
of the contralateral AVCN at three and nine months after
monaural ligation. However, GFAP-IR was found in the
superficial and deep layers of the ipsilateral AVCN at
three and nine months after monaural ligation. GFAP-IR
was also found in the superficial layers of the ipsilateral
Offprnt requests to: Dr. Shang-Ming Yu, lnstitute of Anatorny, National
Yang-Ming University, 155, Section 2, Lee-Nung Street, Shih-Pai,
Taipei, Taiwan 11 221, Republic of China
AVCN at six months after monaural ligation. Microcysts
are presumably derived from the detachment of the
myelin sheath from the retracted axons, protrusion of the
myelin sheath, and disruption of the myelin sheath. The
major conclusions were that (1) microcysts were greatly
reduced following acoustical ligation during postnatal
development, and (2) blood vessels and GFAPimmunoreactive
astrocytes may be involved in the
depletion of microcysts for maintaining the homeostasis
of the microenvironment in the cochlear nuclei.
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