Publication: Prognostic significance of metallothionein
expression in correlation with Ki-67 expression
in adenocarcinomas of large intestine
Authors
Dziegiel, Piotr ; Forgacz, J. ; Suder, E. ; Surowiak, P. ; Kornafel, Jan ; Zabel, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The study aimed at determining levels of
metallothionein (MT) and Ki-67 antigen expression in
adenocarcinomas of large intestine and examining
relation of the expression levels with various clinical and
pathological variables. The studies were performed on
81 cases of large intestine adenocarcinoma. Using
immunocytochemistry, expressions of MT (positive
reaction in 73 cases) and of Ki-67 (positive reaction in
79 cases) antigen were examined and the obtained
results were compared with, i.a., grade (G) of the tumour
and depth to which intestinal wall was infiltrated by
individual tumours. Patient survival analysis was also
performed, as correlated to expression levels of the two
antigens. The obtained results permitted to disclose that
the lower was grade of histological differentiation (G2,
G3), the more pronounced was expression of MT and
Ki-67. Also, the deeper was neoplastic infiltration of
intestinal wall, the more pronounced was MT and Ki-67
expression. Despite the relatively strong correlation
between MT expression and Ki-67 expression (r=0.536;
p<0.05), only Ki-67 antigen expression in large intestine
adenocarcinomas was inversely correlated to survival of
the patients. Ki-67 proved to be a better prognostic
marker, as compared to MT, in large intestine
adenocarcinomas.
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Citation
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