Publication: Thyroxine treatment stimulated ovarian follicular angiogenesis in immature hypothyroid rats
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Date
2008
Authors
Jin-Yi Jiang ; Kanako Miyabayashi ; Stefania A. Nottola ; Motoaki Umezu ; Sandra Cecconi ; Eimei Sato ; Guido Macchiarelli
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. The development of mature ovarian follicles
is greatly dependent on healthy thecal angiogenesis.
Recent experimental evidence showed that thyroxine
(T4) treatment promoted ovarian follicle development in
immature hypothyroid (rdw) rats. However, an
involvement of thyroid hormone in ovarian follicular
angiogenesis has not yet been demonstrated. By
morphological and molecular approaches, the present
studies demonstrated that antral follicles in untreated,
T4- or equine chorionic gonadotropin (eCG)-treated rdw
rats were mainly small and/or atretic, and presented a
poorly developed thecal microvasculature with ultrastructural evidence of diffuse quiescent or degenerative
thin capillaries. However, T4 together with eCG
increased the number of large antral and mature follicles
with numerous activated capillaries and ultra-structural
evidence of rich and diffuse angiogenesis in the theca
layer. While T4 alone significantly increased mRNA
expression of vascular endothelial growth factor (VEGF)
and tumor necrosis factor alpha (TNFα), it decreased
that of fetal liver kinase compared with those in the
untreated group. Combined treatment of T4 and eCG
markedly increased mRNA abundance of not only
VEGF and TNFα, but also basic fibroblast growth
factor. These data suggest that T4 may promote ovarian
follicular angiogenesis in rdw rats by up-regulating
mRNA expression of major angiogenic factors.
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