Publication: Ultrastructural localization of substance P-like
immunoreactivity in the intermediolateral column of
spontaneously hypertensive rats and Wistar-Kyoto rats
Authors
Tan, C.K. ; Tang, F.R. ; Ling, E. A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The distribution of substance P in the
intermediolateral column of the upper thoracic spinal
cord of spontaneously hypertensive (SHR) rats and
Wistar-Kyoto (WKY) rats was studied by combined
retrograde tracing of choleragen subunit-B horseradish
peroxidase (CB-HRP) and immuno-electronmicroscopy.
In the TI-T3 segments of the spinal cord, SP-like
immunoreactive products were localized in the cell
bodies and dendrites of the sympathetic preganglionic
neurons as well as in a few pre-axon terminals or axon
terminals. In the neuropil of the intermediolateral
column (ILN), different synaptic configurations were
observed including synaptic contacts between SP-like
positive dendrites and negative axon terminals, and
between SP-like positive axon terminals and SP-like
positive dendrites. Furthermore, a single SP-like positive
dendrite was sometimes postsynaptic to severa1 axon
terminals, a feature typical of glomerular synapses. The
present findings suggest that most of the SP-like
immunoreactive elements in the ILN were of intraspinal
origin derived mainly from the sympathetic preganglionic
neurons in SHR and WKY rats. Since there
was no ultrastructural difference in the distribution of SP
between the neural elements in the ILN of SHR and
WKY rats, the present findings also suggest that SP may
not be directly involved in the hyperactivity of the
sympathetic nervous system in hypertension.
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