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Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact

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dc.contributor.authorDhakal, Hari Prasad
dc.contributor.authorNaume, Bjørn
dc.contributor.authorSynnestvedt, Marit
dc.contributor.authorBorgen, Elin
dc.contributor.authorKaaresen, Rolf
dc.contributor.authorSchlichting, Ellen
dc.contributor.authorWiedswang, Gro
dc.contributor.authorBassarova, A.V.
dc.contributor.authorHolm, Ruth
dc.contributor.authorGiercksky, Karl- Erik
dc.contributor.authorNesland, Jahn M.
dc.date.accessioned2017-11-08T15:45:44Z
dc.date.available2017-11-08T15:45:44Z
dc.date.issued2012
dc.description.abstractRepresentative tumour sections from 468 patients with invasive breast cancer were immunostained for cyclooxygenase-2 (COX-2) and evaluated. The relationships between COX-2 expression, clinical outcome and various clinicopathological variables, including tumour vascularity and disseminated tumour cells (DTC) in the bone marrow were examined. COX-2 expression in invasive breast carcinoma cells was positively associated with oestrogen receptor and/or progesterone receptor positivity (p<0.001). Triple-negative tumours showed no/low COX-2 expression more frequently than other tumour types (p<0.001). Expression of COX-2 was not associated with breast cancer-specific survival (p=0.49, log-rank) or distant disease-free survival (p=0.67, log-rank) for all patients, including lymph node-negative, untreated patients (p>0.14, log-rank). There was also no significant association between COX-2 expression and histological grade, tumour size, nodal status, DTC in bone marrow, p53, HER2, or tumour vascularity. In conclusion, COX-2 expression in this series was associated with the presence of hormone receptors. Low COX-2 expression was observed in triple-negative breast carcinomas.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 10 (2012)
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/54458
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectBreast canceres
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes
dc.titleExpression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impactes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº10 (2012)