Publication: PIP5K3 upregulation correlates with unfavorable prognosis in patients with nasopharyngeal carcinoma
Authors
Hung-Chang Wu ; Ching-Chieh Yang ; Yun-Tzu Lin ; Chien-Feng Li ; Shih-Lun Chang ; Yu-Hsuan Kuo ; Szu-Chi Yao
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Publisher
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Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-996
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info:eu-repo/semantics/article
Description
Abstract
Background. Nasopharyngeal carcinoma
(NPC) is prevalent in East and Southeast Asia, with
metastasis and recurrence leading to poor prognosis.
Identifying prognostic biomarkers is essential.
Methods. We analyzed differentially expressed
genes involved in the phosphatidylinositol metabolic
process (GO: 0046488) and tumorigenesis (GSE12452)
in NPC. Associations between PIP5K3 expression and
clinicopathological features were assessed using chi
square tests and Cox proportional hazards models.
Results. PIP5K3 was significantly upregulated in
NPC tissues, correlating with advanced stage (p=0.001)
and nodal metastasis (p<0.001). High PIP5K3
expression was associated with worse disease-specific
survival (DSS), distant metastasis-free survival
(DMeFS), and local recurrence-free survival (LRFS).
Multivariate analysis confirmed its association with poor
prognosis (DSS: HR=4.321, DMeFS: HR=2.883, LRFS:
HR=2.249; all p<0.001).
Conclusions. PIP5K3 upregulation is associated with
unfavorable clinical outcomes in NPC and may serve as
a novel prognostic biomarker and potential therapeutic
target.
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