Publication: 8-weeks training program attenuates mitochondrial oxidative stress in the liver of emotionally stressed rats
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Date
2006
Authors
Rosety-Rodriguez, M. ; Ordóñez Muñoz, F.J. ; Rosety, I. ; Frias, L. ; Rosety, M.A. ; Rosety, J.M. ; Rosety, M.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In recent years it has been shown that
emotional stress induced by immobilization may change
the balance between pro-oxidant and antioxidant factors
inducing oxidative damage. On the other hand,
contradictory views exist concerning the role of physical
activity on redox metabolism. Consequently, the present
work was designed to assess the influence of an 8-week
moderate swimming training program in emotionally
stressed rats.
Sixty 1-month-old male albino Wistar rats weighing
125-135 g were used in this experimental study. They
were divided into three groups, as Control (lot A; n=20),
Stressed (lot B; n=20) and Stressed & Exercised (lot C;
n=20). Rats were stressed by placing the animals in a 25
x 7 cm plastic bottle 1 h/day, 5 days a week for 8 weeks.
Protein carbonyl content values in liver homogenates
were significantly increased in stressed animals
(0.58±0.02 vs 0.86±0.03; p=0.018) which clearly
indicated that emotional stress was associated with
oxidative stress. Ultrastructural alterations,
predominantly mitochondrial swelling and the decrease
of cristae number observed by electron microscopy
represented direct evidence of membrane injury.
The most striking feature of our study was that we also found differences between stressed rats and stressed
rats that performed our 8 week training program.
Consequently our results highlight the potential benefit
of a moderate training program to reduce oxidative
damage induced by emotional stress since it attenuated
protein oxidation and mitochondrial alterations.
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