Publication: Argyrophilia in ovarian serous tumors. A comparative study in 127 epithelial ovarian tumors
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Date
1991
Authors
Meisui Lin ; Jun Hanai ; Hakira Wada ; Masami Ozaki ; kenji Nasu ; Shigeru Okamoto ; Keishi Matsumoto
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The distribution of argyrophil cells in
epithelial ovarian tumors was studied in 127 cases. The
results showed that not only mucinous tumors and
endometrioid tumors contained argyrophil cells, but also
some serous tumors expressed argyrophilia. 31% of
serous tumors including 40% of serous adenocarcinomas
contained variable numbers of argyrophil cells.
Argyrophilia has been demonstrated in mucinous
tumors, endometrioid tumors and Brenner tumors
before. However, this is the first time the presence of
argyrophilia in serous tumors has been noticed.
Moreover, the argyrophil cells in 5 serous carcinomas
showed reactivity with Neuroendocrine (chromogranin
A) antibody but not with serotonin. The expression
pattern of argyrophilia in the serous tumors was different
from that of the mucinous tumors; in the former,
argyrophil granules appeared in apical portions or
throughout the cytoplasm of single or clustered cells. In
addition, the argyrophilia in some serous tumors and
endometrioid tumors decreased after diastase digestion Ultrastructurally, no typical neurosecretory granule was
found in the argyrophilic serous tumors. The findings in
this study suggest that argyrophilia could be quite
frequently found in ovarian epithelial tumors and in itself
is not a very specific differential characteristic of
carcinoid tumors. The argyrophilia found in a variety of
epithelial ovarian tumors might lend additional support
to the histogenesis and close relationship between the
common epithelial tumors of the ovary.
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