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GLUT-1 expression is helpful to distinguish myxofibrosarcoma from nodular fasciitis

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dc.contributor.authorNakayama, Shizuhide
dc.contributor.authorNishio, Jun
dc.contributor.authorAoki, Mikiko
dc.contributor.authorKoga, Kaori
dc.contributor.authorNabeshima, Kazuki
dc.contributor.authorYamamoto, Takuaki
dc.date.accessioned2023-03-08T16:06:39Z
dc.date.available2023-03-08T16:06:39Z
dc.date.issued2023
dc.description.abstractMyxofibrosarcoma (MFS) is a fibroblastic/ myofibroblastic neoplasm with a variably myxoid stroma. Histologically, MFS shows a wide spectrum of cellularity, pleomorphism and proliferative activity. Because of its variable morphology and lack of discriminatory markers, MFS can be difficult to distinguish from some benign soft-tissue tumors, especially nodular fasciitis (NF). Glucose transporter 1 (GLUT-1) is expressed in a variety of malignant mesenchymal tumors. In the current study, we evaluated GLUT-1 expression to determine its value in distinguishing MFS from NF. Tissue specimens from 14 MFS cases and 16 NF cases were sectioned and stained for GLUT-1 using immunohistochemistry. The percentage of GLUT-1-positive cells was scored as follows: 0 (no staining), 1+ (1-19%), 2+ (20-50%) and 3+ (>50%). Samples with a score of 1+ were defined as GLUT1-expressing samples. GLUT-1 expression was seen in all 14 MFS cases, whereas only 6 NF cases (37.5%) were positive for GLUT-1 and were scored 1+. Notably, 2-3+ GLUT-1 expression was found in 86% of MFS cases and 0% of NF cases. Our results indicate that GLUT-1 is a highly sensitive immunohistochemical marker for MFS and may be useful for the differential diagnosis of MFS and NF.es
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dc.format.extent5es
dc.identifier.citationHistology and Histopathology Vol. 38, nº1 (2023)
dc.identifier.doihttps://doi.org/ 10.14670/HH-18-490
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129208
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMyxofibrosarcomaes
dc.subjectNodular fasciitises
dc.subjectImmunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleGLUT-1 expression is helpful to distinguish myxofibrosarcoma from nodular fasciitises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº1 (2023)