Publication: Periostin: Novel diagnostic and therapeutic target for cancer
Authors
Kudo, Y. ; Siriwardena, B.S.M.S. ; Hatano, H. ; Ogawa, I. ; Takata, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Periostin is a secreted protein that shares a
structural homology to the axon guidance protein
fasciclin I (FAS1) in insects and was originally named as
osteoblast-specific factor-2 (Osf2). Periostin is
particularly highly homologus to ßig-h3, which
promotes cell adhesion and spreading of fibroblasts. It
has recently been reported that Periostin was frequently
overexpressed in various types of human cancers.
Although the detailed function of Periostin is still
unclear, Periostin-integrin interaction through FAS1
domain is thought to be involved in tumor development.
In addition, Periostin stimulates metastatic growth by
promoting cancer cell survival, invasion and
angiogenesis. Therefore, Periostin can be a useful
marker to predict the behavior of cancer. This review
summarizes the recent understanding of Periostin roles
in tumor development and speculates on the usefulness
of Periostin as a therapeutic and diagnostic target for
cancer.
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