Publication:
Differential requirements of naive and memory T cells for CD28 costimulation in autoimmune pathogenesis

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dc.contributor.authorPerrin, P.J.es
dc.contributor.authorLovett-Rackez, A.es
dc.contributor.authorPhillips, S.M.
dc.contributor.authorRacke, M.K.
dc.date.accessioned2011-02-22T11:09:50Z
dc.date.available2011-02-22T11:09:50Z
dc.date.issued1999
dc.description.abstractExperimental autoimmune encephalomyelitis (EAE) is the most extensively studied animal model of the human disease multiple sclerosis (MS). In EAE, CNS demyelination is induced by immunization with myelin proteins or adoptive transfer of myelin-reactive C D ~ +T cells. Since the antigen specificity of the immune response believed to be responsible for the pathology of MS is not well defined, therapies that target aspects of T cell activation that are not antigen specific may be more applicable to the treatment of MS. As a result, understanding the role of costimulatory molecules in the activation of nai've and memory T cells has become an area of extensive investigation. Naive T cells require two signals for activation. Signal one is provided by engagement of the T cell receptor (TCR) with MHCIpeptide complexes and provides antigen specificity to the immune response. The second signal, termed costimulation, is usually provided by B7 molecules on APC to CD28 molecules expressed on T cells and is antigen-independent. This review will discuss our current understanding of costimulation in the induction and perpetuation of EAE, as well as the potential of costimulaton blockade in the treatment of MS.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19232
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAutoimmunityes
dc.subjectCostimulationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleDifferential requirements of naive and memory T cells for CD28 costimulation in autoimmune pathogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.14, nº 4 (1999)