Publication: Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal
tract by the expression pattern of acyl-CoA synthetase 5
Authors
Gassler, N. ; Obermüller, N. ; Keith, M. ; Schirmacher, P. ; Autschbachl, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Metaplastic and heterotopic epithelia are
frequently found in the human intestine. The recently
cloned human acyl-CoA synthetase 5 (ACS5) is a key
enzyme in providing cytosolic acyl-CoA thioesters. The
aim of the study was to identify and to locate the
expression of ACS5 in the gastric body and the small
intestine with metaplasia or heterotopia by different
methods. In the normal gastrointestinal tract, ACS5 was
predominantly found in the villus epithelium of the small
intestine, but not in the gastric mucosa. Of note, strong
expression of ACS5 was also detectable in intestinal
metaplasia of the stomach. Inversely, ACS5 expression
could neither be detected in heterotopic gastric mucosa
of the corpus type nor in gastric, pseudopyloric, or antral
metaplasia of the small intestine. In conclusion, our data
implicate that ACS5 is a suitable differentiating marker
molecule in the gastrointestinal tract.
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Citation
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