Publication: Ectasias of the subcapsular sinus in lymph nodes of athymic and euthymic rats, a relation to immunodeficiency
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Date
1997
Authors
Sainte-Marie, G. ; Peng, F.S. ; Guay, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This paper describes a morphologically
unusual feature occurring in lymph nodes of some aged
euthymic animals but mostly athymic animals. It initially
consists of small alveole-like excrescences of the cortical
wall of the subcapsular sinus. With dilatation, an
excrescence becomes an ectasia which expands into the
cortex. Observations suggest that ectasias enlarge under
the influence of an increased pressure of the afferent
lymph of a node. Such condition conceivably results
from a greater lymph formation due to inflamation of the
drained tissue site, combined with an impairment to the
flow of lymph from the subcapsular sinus into medullary
sinuses. A probable relation of ectasia formation to
immunodeficiency is discussed. This fonnation results in
the atrophy of the affected lymphoid cell populations of
a node which likely contributes to aggravate the
deficiency of the immune system.
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Citation
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