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Spanish experience with heart transplants from controlled donation after the circulatory determination of death using thoraco-abdominal normothermic regional perfusion and cold storage

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dc.contributor.authorMiñambres, Eduardo
dc.contributor.authorRoyo Villanova, Mario
dc.contributor.authorPérez Redondo, Marina
dc.contributor.authorColl, Elisabeth
dc.contributor.authorVillar García, Susana
dc.contributor.authorCánovas López, Sergio
dc.contributor.authorNistal, Juan Francisco
dc.contributor.authorGarrido, Iris P.
dc.contributor.authorGómez Bueno, Manuel
dc.contributor.authorCobo, Manuel
dc.contributor.authorDomínguez Gil, Beatriz
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.date.accessioned2024-07-18T10:40:44Z
dc.date.available2024-07-18T10:40:44Z
dc.date.issued2021-04
dc.description© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons. This document is the Published version of a Published Work that appeared in final form in American Journal of Transplantation. To access the final edited and published work see https://doi.org/10.1111/ajt.16446
dc.description.abstractHeart transplantation from controlled donation after the circulatory determination of death (cDCDD) may help to increase the availability of hearts for transplantation. During 2020, four heart transplants were performed at three different Spanish hospitals based on the use of thoraco-abdominal normothermic regional perfusion (TA-NRP) followed by cold storage (CS). All donors were young adults <45 years. The functional warms ischemic time ranged from 8 to 16 minutes. In all cases, the heart recovered sinus rhythm within 1 minute of TA-NRP. TA-NRP was weaned off or decreased <1L within 25 minutes. No recipient required mechanical support after transplantation and all were immediately extubated and discharged home (median hospital stay: 21 days) with an excellent outcome. Four livers, eight kidneys, and two pancreata were also recovered and transplanted. All abdominal grafts recipients experienced an excellent outcome. The use of TA-NRP makes heart transplantation feasible and allows assessing heart function before organ procurement without any negative impact on the preservation of abdominal organs. The use of TA-NRP in cDCDD heart donors in conjunction with cold storage following retrieval can eliminate the need to use ex situ machine perfusion devices, making cDCDD heart transplantation economically possible in other countries.es
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dc.format.extent6es
dc.identifier.citationAm J Transplant. 2021 21:1597–1602
dc.identifier.doihttps://doi.org/10.1111/ajt.16446
dc.identifier.issnPrint: 1600-6135
dc.identifier.issnElectronic: 1600-6143
dc.identifier.urihttp://hdl.handle.net/10201/143200
dc.languageenges
dc.publisherWiley
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.amjtransplant.org/article/S1600-6135(22)08507-0/fulltext
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectClinical research/practisees
dc.subjectDonors and donation: donation after circulatory death (DCD)es
dc.subjectExtracorporeal membrane oxygenation (ECMO)es
dc.subjectHeart (allograft) function/disfunctyones
dc.subjectHeart transplantation/cardiology
dc.subjectOrgan procurement and allocation
dc.titleSpanish experience with heart transplants from controlled donation after the circulatory determination of death using thoraco-abdominal normothermic regional perfusion and cold storagees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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