Publication:
Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes

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dc.contributor.authorKim, G.es
dc.contributor.authorRajasekaran, Sigrid A.es
dc.contributor.authorThomas, G.
dc.contributor.authorRosen, E.A.
dc.contributor.authorLandaw, E.M.
dc.contributor.authorShintaku, P.
dc.contributor.authorLassman, C.
dc.contributor.authorSaid, J.
dc.contributor.authorRajasekaran, Ayyappan K.
dc.date.accessioned2011-06-30T12:00:02Z
dc.date.available2011-06-30T12:00:02Z
dc.date.issued2005
dc.description.abstractJunctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell lines cultured in the laboratory generally lack junctional complexes. However, studies directed towards understanding the distribution of junctional complexes in human cancer tissues are lacking. In this study, we analyzed by electron microscopy the distribution of junctional complexes in patients diagnosed with renal clear-cell carcinoma. We found that both tight junctions and adherens junctions were drastically reduced in patients with cancer compared to normal tissues. Desmosomes were not detected in normal proximal tubules while distinctly present in cancer tissues. These results suggest that analysis of junctional complexes in human tumors should provide valuable information that might have prognostic and diagnostic value.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22461
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDesmosomees
dc.subjectTight junctiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleRenal clear-cell carcinoma: an ultrastructural study on the junctional complexeses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 1 (2005)