Publication: Hyaline-vascular type of Castleman's disease
(angiofollicular lymph node hyperplasia) with monotypic
plasma cells. An immunohistochemical study with
monoclonal antibodies
Authors
Chilosi, M. ; Menestrina, F. ; Lestani, M. ; Bonetti, F. ; Scarpa, A. ; Caligaris Cappio, F. ; Pizzolo, G. ; Perini, A. ; Fioredonati, L
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A case of angiofollicular lymph node
hyperplasia (Castleman's disease) characterized by
nionotypic (1gG + , 1arnbda-t) plasrnacytosis is described.
I'resh tissue was available and a thorough
iiiiunohistocheniical analysis of lymphoid and noiilyniphoid
cells was performed on cryostat sections.
Although lyrnphoid follicles were nurnerous and exhibited
sonie abnormal features they did not appear part of the
nionocloiial cell proliferatiun. Follicular lymphocytes were
niixtures of Kappai and 1arnbda-t cells. Vessels
penetrating within these abnormal follicles expressed
reduced levels of FVlll and Leu-M5 antigens and exhibited
thicker layer oí collagen type IV. The analysis of T-cell
subsets showed a normal (3:l) T4/T8 ratio. This case
extends to the mixed variant of hyaline-vascular
Castleman's disease, the neoplastic potential previously
associated to the plasrria cell variant of the disease.
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