Publication: Pattern of degeneration of the rat
inferior olivary complex after the early
postnatal axotomy of the olivocerebellar projection
Authors
Armengol, J.A. ; López-Román, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Neuronal death of inferior olivary neurons
after early axotomy of the olivocerebellar tract was
studied in newborn (Pl) hemicerebellectomized rats
during the first six days after lesion. The degeneration of
the inferior olive showed a topographic pattem from one
(P2) to six days after axotomy (P7), after which this
complex had almost completely disappeared. The first
degenerative changes were observed in the principal
olive (P2), while the media1 accessory olive was the
later-degenerated area (P5). The analysis of these
degenerative changes provides a reference for future
experimental studies. Furthermore, the topographic
study of the degenerative process demonstrated that: i)
the most vulnerable neurons were dorsolaterally located,
whereas the most resistant ones occupied the media1
aspect of the inferior olivary complex, ii) the comparison
between the topographical arrangement of the inferior
olivary neurons according to their birth dates, and the
rate of degenerative changes observed after hemicerebellectomy,
open the possibility that the neurona1
generation date and the response to the axotomy of the
inferior olivary neurons could be related.
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