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Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome

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dc.contributor.authorMuñoz-Prieto, Alberto
dc.contributor.authorCerón, José J.
dc.contributor.authorRubio, Camila P.
dc.contributor.authorContreras-Aguilar, María Dolores
dc.contributor.authorPardo-Marín, Luis
dc.contributor.authorAyala de la Peña, Ignacio
dc.contributor.authorMartín-Cuervo, María
dc.contributor.authorHolm Henriksen, Ida-Marie
dc.contributor.authorTecles, Fernando
dc.contributor.authorHansen, Sanni
dc.contributor.authorArense Gonzalo, Julián Jesús
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2024-09-10T08:33:48Z
dc.date.available2024-09-10T08:33:48Z
dc.date.issued2022-11-23
dc.description© 2022. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in Animals To access the final work, see DOI: https://doi.org/10.3390/ani12233261es
dc.description.abstractIn this report, the measurement of salivary biomarkers as an aid for diagnosis of equine gastric ulcer syndrome (EGUS) was studied. A comprehensive panel of 23 salivary analytes was measured in the saliva of horses affected by EGUS and compared to healthy animals and horses with other diseases clinically similar to EGUS but with a negative diagnosis at gastroscopic examination. A total of 147 horses were included in the study and divided into heathy population (n = 12), the EGUS group (n = 110), and the group of horses with other diseases (n = 25). From the 23 analytes studied, 17 showed increased values in EGUS horses when compared to healthy ones, and uric acid, triglycerides, and calcium were significantly increased in horses with EGUS compared to the group of other diseases. The receiver operating characteristic curve analyses showed a modest but significant discriminatory power of those three analytes to identify EGUS from other diseases with similar symptoms. The discriminatory power enhanced when the results of the three analytes were combined. In conclusion, the results showed that selected salivary analytes could have potential use as biomarkers in horses with EGUS.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationAnimals 2022, 12(23), 3261
dc.identifier.doihttps://doi.org/10.3390/ani12233261
dc.identifier.issnElectronic: 2076-2615
dc.identifier.urihttp://hdl.handle.net/10201/143785
dc.languageenges
dc.publisherMDPIes
dc.relationThis research was funded by the Seneca foundation of Murcia Regional Government, Spain, grant number 19894/GERM/15. C.P.R. was granted by the postdoctoral program ‘Juan de la Cierva Formación’ supported by the ‘Ministerio de Economía y Competitividad’, grant number FJC2019-042475-I), Spain.es
dc.relation.publisherversionElectronic: 2076-2615es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectEquine gastric ulcer syndromees
dc.subjectHorsees
dc.subjectSalivaes
dc.subjectBiomarkerses
dc.subjectDiagnosises
dc.titleEvaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndromees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationbd30abc2-f9f7-4d31-99e6-f05b5b0c0a8e
relation.isAuthorOfPublication.latestForDiscoverybd30abc2-f9f7-4d31-99e6-f05b5b0c0a8e
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