Publication: Autoradiographic investigation of circadian rhythms in alveolar bone periosteum and cementum in young mice
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Date
1987
Authors
Tonna, E.A. ; Singh, I.J. ; Sandhu, H.S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This report presents circadian rhythms in cell
proliferation of alveolar bone periosteum and cementum
of the maxillary first molars of male 5-week-old BNL,
Swiss albino mice which were maintained on a 12 hr light1
dark cycle. Mice were injected with 3H-TDR (lucilgm.
body wt.) 1 hr prior to sacrifice and killed every 3 hrs for
24 hrs starting at 9 a.m. Maxillae were decalcified,
routinely processed histologically and autoradiographs
prepared. Cell labeling indices of alveolar bone and
cementum mesial to the first molar were determined.
Alveolar bone periosteal and cemental cells show
circadian rhythm in their DNA synthetic processes.
Peaks in percent labeling exhibit higher values than
previously reported for nontraumatized, normal dental
periosteum and cementum. While the outer periosteum
reveals a single 24 hr peak (6 p.m.), inner periosteum and
cementum reveal two ultradian peaks 9 to 12 hrs apart
involving both light and dark periods. Rodents are
nocturnal, but high peaks are also evident in the light
periods, consequently, not all peaks are synonymous
with the period of animal activity and feeding. Although
the single daylight peak of the outer periosteum may
indicate growth of that surface at night to about noon,
the double peaks exhibited by inner periosteum and
cementum indicate lightldark, continuously active
surfaces in terms of DNA synthesis and growth
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