Publication: Ultrastructure of granulosa lutein cells from rats fed hexachlorobenzene
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Date
1993
Authors
MacPhee, I.J. ; Singh, Amreek ; Wright, Glenda M. ; Foster, W.G. ; LeBlanc, N.N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Corpora lutea from Sprague-Dawley rats that
were orally administered 0.0 (control), 1.0, 10.0, and
100.0 mglkg hexachlorobenzene (HCB) for 21 days
were analyzed by electron microscopy. Granulosa lutein
cells (GLC) from animals of the 10.0 mg group showed
differences from the cells of animals that served as the
controls. Golgi complexes and smooth endoplasmic
reticulum appeared more conspicuous, possibly due to
dilation resulting from hyperactivity. Free polysomes
seemed more prominent in the cells of the 10.0 mg
group. The GLC architecture from animals of the 1.0
and 100.0 mg groups was similar to that of the
corresponding cells in the control group. Since smooth
endoplasmic reticulum is involved in the synthesis of
steroid hormones, and that free polysomes are engaged
in synthesis of cytoplasmic proteins, it is suggested that
HCB at a dose of 10.0 mglkg given for 21 days may
alter the synthetic activity of the GLC of the rat.
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