Publication: Diapedesis of thrombocytes from capillary into the intercellular space of interscapular brown adipose tissue and their increase by Ca-Sandoz
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Date
1998
Authors
Radovanovic, J. ; Korac, A. ; Koko, V. ; Nedeljkovic, M. ; Drndarevic, N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Diapedetic capacity of the rat thrombocytes
to leave capillaries of the interscapular brown adipose
tissue (IBAT) and infiltrate the interstitium has been
observed by conventional electron-microscopy.
Thrombocytes that reach IBAT interstitium are
morphologically completely different from lumenary
ones. The interstitial thrombocyte has a prominet head
region (1.51x2.12 pm) and very long phylopodium (3.43
pm). Experimental conditions which induced drastic
changes in morphology of interstitial thrombocytes
were: sucrose overfeeding (10% over 2 days); a 24 hour
starving after sucrose overfeeding and Ca-Sandoz
drinking (480 mg/L ca2+ during 2 days). The thrombocytes
in the IBAT interstitium can be classified,as
activated according to: a) pseudopode extension; b)
swollen open canalicullar system (OCS); c) endocytosis
via coated pits and vesicles; and d) structural changes in
a granules excreted to the interstitium through OCS.
In the IBAT interstitium of 24-hour starved rats after
sucrose overfeeding, a thrombocytic layer was observed.
It was suggested that thrombocyte adrenalin, stored in
dense bodies, was selectevely included in the IBAT
supply without mediation of the central nervous system.
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