Publication: Gene products involved in metastasis of bladder cancer
Authors
Davies, B.R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Metastasis is usually responsible for
mortality in patients suffering from muscle invasive
bladder cancer. Whilst expression of a great number of
genes and their protein products have been associated
with metastasis and/or poor prognosis in bladder cancer,
evidence that they actively drive the metastatic process,
and hence make potentially good therapeutic targets, is
often lacking. This is due to the limited number and
application of effective animal models which reflect the
pathogenesis of the human disease. In this review I will
discuss the processes involved in metastasis, consider
the established animal models of bladder cancer
progression and metastasis, and review the evidence for
a role of various gene products in this process.
Consideration of clinical studies in conjunction with
evidence from experimental animal models reveals that
the tyrosine kinase receptor erbB1/EGFR, the calcium
binding protein S100A4 and the the cell cycle
arrest/apoptosis-inducing p53 protein are amongst the
most promising targets for therapy against metastatic
disease in patients with bladder cancer.
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