Publication:
Spontaneous intracerebral hemorrhage as presentation of atypical central neurocytoma: the role of angiogenesis through the characterization of tumor endothelial cells

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Marfia-33-665-672-2018.pdf(6.48 MB)
Date
2018
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Authors
Marfia, Giovanni ; Pirola, Elena ; Navone, Stefania Elena ; Beretta, Matteo ; Guarnaccia, Laura ; Trombetta, Elena ; Franzini, Andrea ; Rampini, Paolo ; Campanella, Rolando
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Publisher
Universidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­a
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DOI
DOI: 10.14670/HH-11-953
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info:eu-repo/semantics/article
Description
Abstract
A 36-year-old white man presented with sudden-onset headache and rapid deterioration of consciousness. Computer tomography revealed a right capsular intra-parenchimal hemorrhage with an intraventricular component; therefore, emergency surgery was performed. Once the hematoma was evacuated, the cause of the hemorrhage was identified as a tumor mass and it was resected. Histopathological and immunohistochemical examinations of the surgical specimen disclosed a diagnosis of atypical central neurocytoma. By using a protocol recently set up in our laboratory, we succeeded in isolating and propagating, for the first time, human endothelial cells from central neurocytoma (CN-ECs). Different analyses revealed that isolated CNECs consist of a pure endothelial cell population, with the expression of endothelial markers (CD31, CD309/VEGFR2, CD105, eNOS) and with angiogenic properties, such as the uptake of LDL. Moreover, CNECs spontaneously organize in a vascular-like structure. The goal of this case report is to stress the need for further studies focused on understanding the causes of the onset of an intra-parenchimal hemorrhage in the presence of an atypical central neurocytoma in order to tailor treatments to each single patient and achieve the best clinical outcome.
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Brain tumor , Neurocytoma , Spontaneous intracranial hemorrhage , Endothelial cells , Glioblastoma
Citation
Histology and Histopathology, Vol.33, nÂş7, (2018)
URI
http://hdl.handle.net/10201/119644
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Histology and histopathology Vol.33, nÂş7 (2018)
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