Publication: Central giant cell granuloma of the jawbones - new insights into molecular biology with clinical implications on treatment approaches
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Date
2008
Authors
Vered, Marilena ; Buchner, Amos ; Dayan, Dan
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Central giant cell granulomas (CGCG)
constitute about 10% of benign jawbone lesions.
Approximately one-third of CGCG exhibit local
aggressive behavior with bone destruction and a
tendency to recur. Cure of patients with aggressive
CGCG can be achieved by en bloc resection with clear
margins at the possible cost of esthetic, functional and
psychological problems, mainly in young patients. It is
in these cases where pharmacologic agents are most
needed as an alternative treatment approach. Until now,
pharmacologic agents for CGCG have been used
empirically and, in a small number of cases, with various
degrees of success. The purpose of this review is to
present the recent findings on the phenotypic profile of
the constituent cells in CGCG at the molecular level and
discuss the inter-relations among them; to analyze the
osteolytic potential concealed in the lesional cells; to
provide an evidence-based rationale for the use of
pharmacologic agents, and, consequently, to suggest a
revised approach for their use.
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