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Leukotrienes, But Not Angiotensin II, Are Involved in the Renal Effects Elicited by the Prolonged Cyclooxygenase-2 Inhibition When Sodium Intake Is Low

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dc.contributor.authorSalazar, Francisco
dc.contributor.authorSalazar, F. Javier
dc.contributor.authorSaez, Fara
dc.contributor.authorReverte, Virginia
dc.contributor.authorZweifel, Ben
dc.contributor.authorDufield, Dawn
dc.contributor.authorRadabaugh, Melissa
dc.contributor.authorGraneto, Matt
dc.contributor.authorLlinas, María Teresa
dc.contributor.authorMasferrer, Jaime L.
dc.contributor.departmentFisiología
dc.date.accessioned2025-03-18T12:44:43Z
dc.date.available2025-03-18T12:44:43Z
dc.date.issued2013-04
dc.description© 2013 Lippincott, Williams & Wilkins This document is the accepted version of a published work that appeared in final form in Journal of Cardiovascular Pharmacology. . To access the final edited and published work see: https://doi.org/10.1097/FJC.0b013e31828399ae
dc.description.abstractIt is known that cyclooxygenase-2 (COX-2) inhibition elicits significant renal hemodynamics alterations when sodium intake is low. However, the mechanisms involved in these renal changes are not well known. Our objective was to evaluate the role of angiotensin II and 5-lipooxygenase-derived metabolites in the renal effects induced by prolonged COX-2 inhibition when sodium intake is low. Conscious dogs were treated during 7 days with a COX-2 inhibitor (1 mg·kg−1·d−1, SC75416), and either a vehicle, an AT1 receptor antagonist (0.4 mg·kg−1·d−1, candesartan) or a selective 5-lipooxygenase inhibitor (PF-150, 20 and 60 mg·kg−1·d−1). The administration of SC75416 alone induced significant changes in renal blood flow (219 ± 14 to 160 ± 10 mL/min), glomerular filtration rate (51 ± 2 to 42 ± 3 mL/min), and plasma potassium (pK) (4.3 ± 0.1 to 4.6 ± 0.1 mEq/L). Similar decrements in renal blood flow (27%) and glomerular filtration rate (20%) and a similar increment in pK (7%) were found when SC75416 was administered in candesartan-pretreated dogs. However, SC75416 administration did not elicit significant changes in renal hemodynamics and pK in dogs pretreated with each dose of PF-150. Our data suggest that leukotrienes but not angiotensin II are involved in the renal effects induced by COX-2 inhibition when sodium intake is low.es
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dc.format.extent8
dc.identifier.citationJournal of Cardiovascular Pharmacology 61(4):p 329-336
dc.identifier.doihttps://doi.org/10.1097/FJC.0b013e31828399ae
dc.identifier.issnPrint.: 0160-2446
dc.identifier.issnElectronic.: 1533-4023
dc.identifier.urihttp://hdl.handle.net/10201/151791
dc.languageenges
dc.publisherLippincott, Williams & Wilkins
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://journals.lww.com/cardiovascularpharm/abstract/2013/04000/leukotrienes,_but_not_angiotensin_ii,_are_involved.10.aspx
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.titleLeukotrienes, But Not Angiotensin II, Are Involved in the Renal Effects Elicited by the Prolonged Cyclooxygenase-2 Inhibition When Sodium Intake Is Lowes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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