Publication: Gene therapy using herpes simplex virus-based vectors
Authors
Latchman, D.S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Gene therapy involves the use of specific
genes to treat human diseases and is thus critically
dependent on efficient gene delivery systems. Although
a variety of systems for such gene delivery are under
development, HSV has unique advantages in terms of its
large genome size and for gene delivery in the nervous
system because of its ability to enter a latent state in
neuronal cells. Considerable progress has been made in
the effective disablement of this virus whilst retaining its
ability to deliver genes and in producing long term
expression of the foreign gene. Although much remains
to be achieved in the further disablement of the virus and
its testing in rodent and primate models of human
diseases, it is likely that these viruses may ultimately be
of use in human gene therapy procedures particularly for
otherwise intractable neurological diseases.
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