Publication: Leukotriene synthesis by epithelial cells
Authors
Luo, M. ; Lee, S. ; Brock, T.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Leukotrienes (LTs) are intercellular signaling
molecules that evoke a variety of responses. They are
best known as potent promoters of inflammation.
Normally, LTs are produced primarily by leukocytes. As
a result, current models regarding the production of LTs
in the context of disease focus on the leukocytes as the
site of production. Structural cells, including epithelial
cells, are typically relegated to supportive roles. It is
recognized that epithelial cells normally contain all the
components necessary for LT synthesis except the
enzyme 5-lipoxygenase (5-LO). There is accumulating
evidence that some populations of epithelial cells
normally express low levels of 5-LO and can synthesize
LTs autonomously. Moreover, certain factors, including
bacterial and viral infection, can promote the expression
of 5-LO in airway, gastrointestinal and skin epithelial
cells. The appearance of active 5-LO enzyme in
epithelial cells at these sites may contribute to diseases
like cancer, colitis and psoriasis. This paper reviews the
state of our knowledge regarding the expression of 5-LO
in epithelial cells, the factors that modify that
expression, and the implications regarding pathogenesis.
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