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HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19

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dc.contributor.authorCastro-Santos, Patricia
dc.contributor.authorRojas-Martinez, Augusto
dc.contributor.authorRiancho, José A.
dc.contributor.authorLapunzina, Pablo
dc.contributor.authorFlores, Carlos
dc.contributor.authorCarracedo, Angel
dc.contributor.authorDíaz-Peña, Roberto
dc.contributor.authorGarcía-Vázquez, Elisa
dc.contributor.authorScourge Cohort Group
dc.contributor.departmentMedicina
dc.date.accessioned2024-07-08T10:51:19Z
dc.date.available2024-07-08T10:51:19Z
dc.date.issued2023-08-01
dc.description© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This document is the Published, version of a Published Work that appeared in final form in HLA: Immune Response Genetics. To access the final edited and published work see https://doi.org/10.1111/tan.15160es
dc.description.abstractWe analyzed the association between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from a total of 9373 COVID-19-positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID-19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA-B*14:02 and HLA-C*08:02 with a lower risk to COVID-19 infection (p = 0.006, OR = 0.84, 95% CI = [0.75–0.95], p = 0.024, OR = 0.86, 95% CI = [0.78–0.95], respectively). We also found the alleles HLA-A*11:01 and HLA- C*04:01 associated with disease severity (p = 0.033, OR = 1.16, 95% CI = [1.04–1.31], p = 0.045, OR = 1.14, 95% CI = [1.05–1.25], respectively). These results suggest that an effective presentation of viral peptides by HLA class I alleles involve a faster infection clearance, decreasing the susceptibility and severity of COVID-19.es
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dc.identifier.citationHLA: Immune Response Genetics. 2023 102(6): 731-739
dc.identifier.doihttps://doi.org/10.1111/tan.15160
dc.identifier.issnPrint: 2059-2302
dc.identifier.issnElectronic: 2059-2310
dc.identifier.urihttp://hdl.handle.net/10201/142903
dc.languageenges
dc.publisherJohn Wiley & Sonses
dc.relationInstituto de Salud Carlos III, Grant/Award. Numbers: COV20_00622, CP21/00003; European Union (ERDF)es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/tan.15160es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCOVID-19es
dc.subjectHLA evolutionary divergencees
dc.subjectHLA-A*11:01es
dc.subjectHLA-C*04:01es
dc.subjectImmunogeneticses
dc.subjectSARS-CoV-2es
dc.titleHLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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