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High MET copy number and MET overexpression: Poor outcome in non-small cell lung cancer patients

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dc.contributor.authorPark, Sanghui
dc.contributor.authorChoi, Yoon-La
dc.contributor.authorSung, Chang Ok
dc.contributor.authorAn, Jungsuk
dc.contributor.authorSeo, Jinwon
dc.contributor.authorAhn, Myung-Ju
dc.contributor.authorAhn, Jin Seok
dc.contributor.authorPark, Keunchil
dc.contributor.authorShin, Young Kee
dc.contributor.authorErkin, Ozgur Cem
dc.contributor.authorSong, Kyung
dc.contributor.authorKim, Jhingook
dc.contributor.authorShim, Young Mog
dc.contributor.authorHan, Joungho
dc.date.accessioned2017-03-10T15:43:46Z
dc.date.available2017-03-10T15:43:46Z
dc.date.issued2012
dc.description.abstractThe aim of this study was to evaluate the prevalence and prognostic role of increased gene copy number and protein expression of MET and EGFR in non-small cell lung cancer (NSCLC) patients. Samples were collected from 380 patients with surgically resected NSCLC, and fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) were performed. EGFR amplification and high polysomy (EGFR FISH-positive) were observed in 9.7% and 17.4% of the patients, respectively. EGFR was overexpressed (EGFR IHC-positive) in 19.2% of the patients. Neither EGFR FISH-positive nor EGFR IHC-positive status affected survival after resection. Increased MET copy number (MET FISH-positive by University of Colorado Cancer Center criteria) was observed in 11.1% of the patients (high polysomy, 8.7%; gene amplification, 2.4%). According to the Cappuzzo system, 7.1% of the patients were MET FISH-positive. MET FISH positivity was a negative prognostic factor, especially in patients with adenocarcinoma histology (p=0.040), female gender (p=0.010), old age (p=0.084), and EGFR FISH negativity (p=0.020) at the univariate level but not at the multivariate level. MET was overexpressed (MET IHC-positive) in 13.7% of the patients and associated with shorter overall and disease-free survival (p=0.010 and p=0.056, respectively). Multivariate analysis revealed that MET IHC-positive patients had a significantly increased risk of death (hazard ratio, 1.618; 95% confidence interval, 1.066-2.456; p=0.024). Increased MET copy number and MET overexpression are negative prognostic factors for surgically resected NSCLCses
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 2 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52407
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCanceres
dc.subjectFISHes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHigh MET copy number and MET overexpression: Poor outcome in non-small cell lung cancer patientses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 2 (2012)