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Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex

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dc.contributor.authorDávila, José Carlos
dc.contributor.authorReal, Mª Angeles
dc.contributor.authorOlmos, Luis
dc.contributor.authorMedina, Loreta
dc.contributor.authorGuirado, Salvador
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T08:44:55Z
dc.date.available2024-07-12T08:44:55Z
dc.date.issued2005-01-03
dc.description© 2004 Wiley-Liss, Inc. This document is the Published version of a Published Work that appeared in final form in Journal of Comparative Neurology. To access the final edited and published work see https://doi.org/10.1002/cne.20347
dc.description.abstractWe analyzed the development of immunoreactive expression patterns for the neurotransmitter γ-aminobutyric acid (GABA) and the calcium-binding proteins calbindin, calretinin, and parvalbumin in the embryonic and postnatal mouse claustral complex. Each calcium-binding protein shows a different temporal and spatial pattern of development. Calbindin-positive cells start to be seen very early during embryogenesis and increase dramatically until birth, thus becoming the most abundant cell type during embryonic development, especially in the ventral pallial part of the claustrum. The distribution of calbindin neurons throughout the claustrum during embryonic development partly parallels that of GABA neurons, suggesting that at least part of the calbindin neurons of the claustral complex are GABAergic and originate in the subpallium. Parvalbumin cells, on the other hand, start to be seen only postnatally, and their number then increases while the density of calbindin neurons decreases. Based on calretinin expression in axons, the core/shell compartments of the dorsal claustrum start to be clearly seen at embryonic day 18.5 and may be related to the development of the thalamoclaustral input. Comparison with the expression of Cadherin 8, a marker of the developing dorsolateral claustrum, indicates that the core includes a central part of the dorsolateral claustrum, whereas the shell includes a peripheral area of the dorsolateral claustrum, plus the adjacent ventromedial claustrum. The present data on the spatiotemporal developmental patterns of several subtypes of GABAergic neurons in the claustral complex may help for future studies on temporal lobe epilepsies, which have been related to an alteration of the GABAergic activity.es
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dc.format.extent16es
dc.identifier.citationJournal of Comparative Neurology, 2005, Vol. 481, Issue 1, pp. 42-57
dc.identifier.doihttps://doi.org/10.1002/cne.20347
dc.identifier.issnPrint: 0021-9967
dc.identifier.issnElectronic: 1096-9861
dc.identifier.urihttp://hdl.handle.net/10201/143058
dc.languageenges
dc.publisherWiley
dc.relationSpanish Dirección General de Investigación-Fondo Europeo de Desarrollo Regional (FEDER); Grant number: BFI2003-06453-C02-01/02; Grant sponsor: Fondo de Investigaciones Sanitarias-FEDER; Grant number: 01/0057-02; Grant sponsor: Séneca; Grant number: PB/50/FS/02; Grant sponsor: Red Centro de Investigación de Enfermedades Neurológicas-Nodo 318.es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/cne.20347
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCalcium-binding proteinses
dc.subjectDorsal claustrumes
dc.subjectEndopiriform nucleuses
dc.subjectImmunohistochemistryes
dc.titleEmbryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complexes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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