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Analysis of the molecular expression profile of non small cell lung carcinoma associated to chronic obstructive pulmonary disease

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dc.contributor.authorGarcia-Lujan, Ricardoes
dc.contributor.authorConde-Gallego, Estheres
dc.contributor.authorLopez-Ríos, Fernando
dc.contributor.authorMartin de Nicolas, Jose Luis
dc.contributor.authorSanchez-Céspedes, Montserrat
dc.contributor.authorGarcía-Quero, Cristina
dc.contributor.authorEchave-Sustaeta, José María
dc.contributor.authorLopez-Encuentra, Angel
dc.date.accessioned2013-09-24T11:34:25Z
dc.date.available2013-09-24T11:34:25Z
dc.date.issued2009
dc.description.abstractChronic obstructive pulmonary disease (COPD) is an independent risk factor to develop lung cancer but there are no different functional clusters of biomarkers between patients with non-small cell lung cancer (NSCLC) with or without COPD. To analyse protein expression, in order to find out whether samples of resected NSCLC from patients with COPD present a different molecular expression. Observational, cohort, concurrent study with sampling since treatment of disease in patients with NSCLC in initial stages (pIApIIB) treated surgically in our hospital between October 1993 and September 1997. The study consisted of the elaboration of tissue arrays with samples from resected tumor, using immunohistochemistry as a study method. Univariate analysis and logistic regression analysis were performed in order to determine molecular markers that showed a differential expression in NSCLC of the patients with COPD. We studied thirty-two proteins in 146 patients. 30% of the patients had COPD. Univariate analysis in patients with COPD showed one molecular marker to be overexpressed and five molecular markers to be underexpressed. Multivariate analysis in patients with COPD identified membranous ß-Catenin as a differential biomarker, which displayed an underexpression, with an Odds Ratio (95% Confidence Interval) of 0.26 (0.07-1.01). A significant lowest expression of membranous ß-catenin was detected in NSCLC of the patients with COPD.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/36005
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectCOPDes
dc.subject.other61 - Medicinaes
dc.titleAnalysis of the molecular expression profile of non small cell lung carcinoma associated to chronic obstructive pulmonary diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24, nº4 (2009)