Publication: The Rho small GTPase Functions in health and disease
Authors
Toksoz, D. ; Merdek, K.D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell shape changes, contractility, adhesion,
migration, gene transcription, cytokinesis, membrane
trafficking, and growth, require Rho small GTPase
function. The basis for this is that Rho regulates actin
filament assembly, and serum response factor (SRF)-
mediated gene transcription. Upon activation by serum
or cell adhesion, Rho stimulates a distinct signal
transduction pathway that induces cytoskeletal and
transcriptional responses through diverse effectors. Rho
activity is tightly controlled by guanine nucleotide
exchange factors, GTPase activating proteins, and
guanine dissociation inhibitors. Dysregulation of the
Rho pathway is implicated in multiple pathological
conditions including cancer and metastasis,
cardiovascular disease, bacterial and viral pathogenesis,
hepatic disease, and developmental disorders.
Citation
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