Publication: Circulating nucleic acids as a tumor marker
Authors
Chan, K.C.A. ; Lo, Y.M.D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Patients suffering from malignant diseases
have been shown to have increased amounts of cell free
nucleic acids in their circulation. As genetic and
epigenetic alterations are increasingly characterized in
different types of tumors, such changes can be used to
detect tumor-derived nucleic acids in the circulation. To
date, nearly all tumor-associated nucleic acids have been
detected in the plasma or serum of cancer patients.
Moreover, increased levels of circulating viral nucleic
acids have also been demonstrated in patients with
certain cancers associated with viral infections. The
concentration of these tumor-associated nucleic acid
species is generally related to the tumor load and the
extent of the disease. Serial monitoring of plasma
nucleic acids thus provides a good way to follow disease
progress and to predict the outcome of such patients. In
this review, different approaches of detecting tumorrelated
nucleic acids in the circulation and their potential
as tumor markers in the screening, monitoring and
prognostication of malignant diseases are discussed.
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