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Molecular and immunohistochemical markers in appendiceal mucinous neoplasms: A systematic review and comparative analysis with ovarian mucinous neoplasms and colorectal adenocarcinoma

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dc.contributor.authorElsayed, Basel
dc.contributor.authorElshoeibi, Amgad Mohamed
dc.contributor.authorElhadary, Mohamed
dc.contributor.authorAl Jubouri, Abdullah M.
dc.contributor.authorAl Qahtani, Noof
dc.contributor.authorVranic, Semir
dc.contributor.authorAl Saad, Rafify
dc.date.accessioned2025-04-28T08:09:54Z
dc.date.available2025-04-28T08:09:54Z
dc.date.issued2025
dc.description.abstractIntroduction. Appendiceal mucinous neoplasms (AMNs) represent a rare and diagnostically challenging group of tumors. This systematic review aims to summarize the reported molecular and immunohistochemical markers (IHC) associated with AMNs and compare them with ovarian mucinous neoplasms (OMNs) and colorectal adenocarcinoma (CRC). Methods. A comprehensive search was performed in PubMed/MEDLINE/PMC, Scopus, Embase, and Web of Science databases to identify studies looking at IHC and molecular markers in AMNs. Chi-squared and Fisher’s exact tests were utilized to compare the marker expression across different tumor types. Results. We identified 27 articles reporting several potential biomarkers for distinguishing between different subtypes of AMNs. Mutations in KRAS, GNAS, and RNF43 emerged as notable biomarkers, with KRAS mutations being the most prevalent across all subtypes. Additionally, p53 IHC overexpression was associated with higher tumor grades. When comparing AMNs with OMNs, we observed a higher prevalence of CK20, CDX2, SATB2, and MUC2 IHC expression, as well as KRAS and GNAS mutations, in AMNs. Conversely, CK7 and PAX8 IHC expression were more prevalent in OMNs. Comparing AMNs with CRCs, we found a higher prevalence of TOPO1 and PTEN IHC expression, as well as KRAS and GNAS mutations, in AMNs. Conversely, nuclear β-catenin IHC expression, as well as TP53, APC, and PIK3CA mutations, were more prevalent in CRCs. Conclusion. This systematic review identified possible markers for distinguishing AMNs and differentiating between AMNs, OMNs, or CRCs.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology Vol. 40, nº05 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-830
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/153503
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAppendiceal mucinous neoplasmes
dc.subjectOvarian mucinous neoplasmes
dc.subjectColorectal adenocarcinomaes
dc.subjectImmunohistochemistryes
dc.subjectMoleculares
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMolecular and immunohistochemical markers in appendiceal mucinous neoplasms: A systematic review and comparative analysis with ovarian mucinous neoplasms and colorectal adenocarcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº5 (2025)