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How does retinoic acid (RA) signaling pathway regulate spermatogenesis?

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dc.contributor.authorZhang, Hua Zhe
dc.contributor.authorHao, Shuang Li
dc.contributor.authorYang, Wan Xi
dc.date.accessioned2023-03-07T08:53:49Z
dc.date.available2023-03-07T08:53:49Z
dc.date.issued2022
dc.description.abstractMale sterility is a worldwide health problem which has troubled many unfortunate families and attracted widespread attention in the field of reproduction. Retinoic acid (RA) is a metabolite of vitamin A. Previous studies have shown that insufficient intake of vitamin A can lead to male infertility. Similarly, RA-deficiency can lead to abnormal spermatogenesis in men. RA signaling is inseparable from hormone stimulation, such as FSH, testosterone and others. It can regulate spermatogenesis as well, including the proliferation and differentiation of spermatogonia, meiosis, spermiogenesis and spermiation. To promote or inhibit spermatogenesis, RA regulates Stra8, Kit, GDNF, BMP4 and other factors in various pathways. At the self-renewal stage, RA inhibits spermatogonia renewal by directly or indirectly inhibiting DMRT, GDNF and Cyclin. At the stage of differentiation and meiosis, RA controls SSC differentiation through Kit induction and Nanos2 inhibition, and controls spermatogonia meiotic entry through up- regulation of Stra8. At the stage of spermiogenesis, RARĪ±, as a key regulator, regulates spermatogenesis by up regulating Stra8 while binding with RA. Although RA plays an important role in all stages of spermatogenesis, RA signaling is more important in the early stage of spermatogonia (spg) differentiation and spermatocyte (spc) meiosis. According to the principle of RA signaling that regulates spermatogenesis, we also speculate on the future clinical application of RA, such as potential induction of SSC in vitro, contraception and restoring spermatogenesis. This paper reviews the regulatory pathways of RA, and prospects the clinical applications of RA signaling in the future.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 37, nĀŗ11 (2022)
dc.identifier.doihttps://doi.org/10.14670/HH-18-478
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129124
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiaciĆ³n externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSpermatogenesises
dc.subjectRetinoic acid, Selfrenewales
dc.subjectProliferationes
dc.subjectDifferentiationes
dc.subjectStra8es
dc.subjectGDNFes
dc.subjectRARes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĆ­a. Medicina clĆ­nica. OncologĆ­aes
dc.titleHow does retinoic acid (RA) signaling pathway regulate spermatogenesis?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.37,nĀŗ11 (2022)