Publication: Aberrant PAX3 and PAX7 expression. A link to the
metastatic potential of embryonal rhabdomyosarcoma
and cutaneous malignant melanoma?
Authors
Blake, J. ; Ziman, M.R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Transcription factors encoded by PAX3 and
PAX7 are amongst the first expressed in the embryo,
being principal regulators of neurogenic and myogenic
progenitor cell specification and embryonic
segmentation. The basis for this review lies in the
supposition that genetic programs for cell migration,
thought regulated by PAX3 and PAX7 during embryonic
development, become tools used by the metastatic cell.
In highly metastatic neoplasms arising from cells of
neurogenic and myogenic lineages such as embryonal
rhabdomyosarcoma and cutaneous malignant melanoma,
markedly high expression levels of PAX3 and PAX7
support this supposition.
As PAX3 and PAX7 are known to play a role in the
regulation of migratory events in embryogenesis, it is
possible that the metastatic potential of these tumours is
directly linked to migratory properties conferred them
through PAX expression.
Here we provide a novel perspective by correlating
metastasis with expression of PAX3, PAX7 and
ephrin/Eph receptors as well as NCAMs, cell surface
markers normally involved in migration and adhesion
during development, and propose a role for PAX genes in
the increased metastatic potential of these tumours.
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