Publication: Ulmtrastructuroef the chronically vagotomised atrial
myocardiu m in t he mon key (Macaca fascicularis)
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Date
1989
Authors
Wong, W. C. ; Yick, T. Y. ; Ling, E. A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The ultrastructure of the atrial myocardium
in the monkey (Macaca fascicularis) was studied after
bilateral cervical vagotomy and survival times of 100,175
and 367 days. Changes were observed in the nucleus and
the cytoplasm of the myocyte. Sequestered within the
nuclei of the affected myocytes were cytoplasmic
organelles and inclusions. In the late stages, there was a
tendency towards condensation and margination of the
heterochromatin. Changes in the cytoplasm included
increased glycogen, mitochondrial degeneration and
myofibrillar disorganisation and degeneration. There
was increased collagen and mononuclear cell infiltration
in the extracellular space in the later stages. This study
has shown that the long term structural integrity of the
atrial myocyte depends on an intact vaga1 innervation.
The survival of the monkey after chronic bilateral
vagotomy suggests that this nonhuman primate is
a suitable model for functional studies of the
parasympathetically denervated heart.
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