Publication: The transcription factor E2F: a crucial switch in the control of homeostasis and tumorigenesis
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Date
2006
Authors
Fang, Z.H. ; Han, Z.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The transcription factor E2F plays a crucial
role in governing cell proliferation through manipulation
of the expression of many genes required for cell cycle
progression. As studies are exploring in depth, E2F has
grown into a multimember family and has been required
for the regulation of a large number of genes involved in
various cellular processes. The expanding E2F
membership and biological function provide us some
new insights relating to the evolution of E2F. One of
them is to understand the exact mechanisms by which
E2F executes in these different cellular processes during
ontogenesis. This review summarizes recent advances in
this field, with an emphasis on a notion that E2F acts as
a molecular switch in the control of both normal cell and
tumor development.
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