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Monitoring of pathogenic Leptospira infection in wolves (Canis lupus) from Spain and Italy

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dc.contributor.authorCano Terriza, David
dc.contributor.authorMoroni, Bárbara
dc.contributor.authorFayos, Manena
dc.contributor.authorMartínez, Remigio
dc.contributor.authorOleaga, Alvaro
dc.contributor.authorRobetto, Serena
dc.contributor.authorRemesar, Susana
dc.contributor.authorOrusa, Ricardo
dc.contributor.authorMuñoz Hernández, Clara
dc.contributor.authorVelarde, Roser
dc.contributor.authorGarcía Bocanegra, Ignacio
dc.contributor.authorGonzálvez Juan, Moisés
dc.contributor.departmentSin departamento asociado
dc.date.accessioned2026-01-19T12:29:26Z
dc.date.available2026-01-19T12:29:26Z
dc.date.copyright© 2024 The Authors
dc.date.issued2024-08-15
dc.description.abstractLeptospirosis is a bacterial disease of worldwide distribution with relevant implications for animal and human health. Different large wild carnivore species can act as reservoirs of this zoonotic pathogen. This study aimed to evaluate the circulation of Leptospira spp. in free-ranging wolves (Canis lupus) from southern Europe. A total of 281 kidney samples of wolves from Spain and Italy were collected between 2017 and 2023. The presence of Leptospira DNA was analysed by real-time PCR and phylogenetic analyses were carried out using a Bayesian approach. The overall prevalence was 3.2 % (9/281; 95 %CI: 1.1–5.3). Leptospira DNA was detected in nine of the 180 wolves from Spain (5.0 %; 95 %CI: 1.8–8.2), but not in the Italian wolf population (0 %; 0/101). Molecular analyses revealed high homology between the sequences obtained in the present study and isolates of Leptospira interrogans and Leptospira borgpetersenii from different rodent and domestic ungulate species. Our results provide evidence of a low and spatially heterogeneous circulation of this pathogen in wolf populations of southern Europe. The detection of zoonotic Leptospira species in this survey supports the need to consider wolf populations in monitoring programs for leptospirosis with a One Health approach.
dc.formatapplication/pdf
dc.format.extent5
dc.identifier.citationVeterinary Microbiology, 2024, Vol. 298 : 110222
dc.identifier.doihttps://doi.org/10.1016/j.vetmic.2024.110222
dc.identifier.eissn1873-2542
dc.identifier.issn0378-1135
dc.identifier.urihttp://hdl.handle.net/10201/188191
dc.languageeng
dc.publisherElsevier
dc.relationThis work was partially supported by CIBER-Consorcio Centro de Investigación Biomédica en Red (CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea-Next Generation EU. M. Gonzálvez and C. Muñoz-Hernández were supported by postdoctoral contracts Margarita Salas (University of Murcia) from the Program of Requalification of the Spanish University System (Spanish Ministry of Universities) financed by the European Union-NextGenerationEU. R. Martínez was supported by a postdoctoral contract (Ref. POSTDOC_21_00041) at the University of Córdoba from the Consejería de Universidad, Investigación e Innovación of the Regional Government (Andalucía, Spain).
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S037811352400244X
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLeptospira
dc.subjectSpain
dc.subjectItaly
dc.subjectWolf
dc.subjectZoonosis
dc.subjectLeptospirosis
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleMonitoring of pathogenic Leptospira infection in wolves (Canis lupus) from Spain and Italy
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublicationed7b26e8-ba82-4424-9d88-9146b063fb8c
relation.isAuthorOfPublicationd0bfa3a6-c4d2-4225-b663-52987a201884
relation.isAuthorOfPublication.latestForDiscoveryed7b26e8-ba82-4424-9d88-9146b063fb8c
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