Publication: Phosphatidylinositide 3-kinase AKT in radiation responses
Authors
Zhan, M. ; Han, Z.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ionizing or ultraviolet radiation-induced
cellular survival signaling pathways induce development
of cancer and insensitivity of tumor cells to radiation
therapy. Accumulating evidence suggests that the
phosphatidylinositide 3-kinase (PI3K)/AKT signal
pathway is a major contributor to radioresistance. In
many cell types PI3K/AKT signaling is a key
cytoprotective response downstream of the EGFR family
receptors and mediated carcinogenesis. Cytokines, such
as HGF, IGF-I, and IL-6 also protects cells against
apoptosis induced by radiation through PI3K/AKT
pathway. The mechanics by which PI3K/AKT signaling
functions in radiation responses may include its
regulation of mitochondrial proteins, transcription
factors, translation machinery, and cell-cycle
progression. In addition, cross-talk between the
PI3K/AKT pathway and mitogen-activated protein
kinases, protein kinase A, and protein kinase C signal
pathway may also play an important role.
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Citation
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