Publication: Rapid urinary antigen test for diagnosis of pneumococcal community-acquired pneumonia in adults
Authors
Marcos, M.A. ; Jiménez de Anta, M.T. ; Bellacasa, J.P. de la ; González, J. ; Martínez, E. ; García-Vázquez, Elisa ; Mensa, J. ; Roux, A. de ; Torres, A.
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Publisher
ERS Journals
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DOI
https://doi.org/10.1183/09031936.03.00058802
Electronic: 1399-3003
Electronic: 1399-3003
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info:eu-repo/semantics/article
Description
©ERS Journals Ltd. This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published, version of a Published Work that appeared in final form in European Respiratory Journal. To access the final edited and published work see https://doi.org/10.1183/09031936.03.00058802
Abstract
Streptococcus pneumoniae is suspected to cause an important proportion of community-acquired pneumonia (CAP) whose aetiology cannot be detected withconventional tests.
In this study, the authors evaluated the diagnostic yield of a new immunochromatographic membrane test (ICT) for the detection of the S. pneumoniae antigen in the urine
of patients admitted with diagnosed CAP. ICT was performed in unconcentrated and concentrated urine from all the patients. ICT was repeated 1 month after discharge in a group initially testing positive. The authors also studied the ICT in clinically stable human immunodeficiency virus type 1 (HIV1)-infected patients.
S. pneumoniae antigen was detected in all of the 68 (100%) patients tested with definitive pneumococcal pneumonia. In five of these cases ICT was only positive when it had been performed on the patients. The
S. pneumoniae antigen was also detected in 36 (69.2%) of 52 patients with probable pneumococcal pneumonia and in 50 of 277 (18%) patients without pneumococcal pneumonia. ICT remained positive in 16 (69.5%) of 23 patients, 1 month after hospital discharge. Nasopharyngeal colonisation with S. pneumoniae
was detected in 8 (12%) of 68 clinically stable HIV1 infected patients, but none tested ICT positive.
The Binax NOW1 immunochromatographic membrane test is a rapid, sensitive and specific test for detecting pneumococcal community-acquired pneumonia in adults. The test may remain positive for several weeks after pneumococcal pneumonia.
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Citation
Eur Respir J 2003 21: 209–214
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