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Epithelial expression of vanilloid and cannabinoid receptors: a potential role in burning mouth syndrome pathogenesis

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dc.contributor.authorBorsani, Elisa
dc.contributor.authorMajorana, Alessandra
dc.contributor.authorCocchi, Marco Angelo
dc.contributor.authorConti, Giulio
dc.contributor.authorBonadeo, Sara
dc.contributor.authorPadovani, Alessandro
dc.contributor.authorLauria, Giuseppe
dc.contributor.authorBardellini, Elena
dc.contributor.authorRezzani, Rita
dc.contributor.authorRodella, Luigi Fabrizio
dc.date.accessioned2019-02-28T10:06:33Z
dc.date.available2019-02-28T10:06:33Z
dc.date.issued2014
dc.description.abstractBurning mouth syndrome (BMS) is an intra-oral burning sensation for which presently no medical or dental causes have been found, and in which the oral mucosa appears normal. It remains an unknown disease for which there is still no long-term treatment. The aim of this study was to assess the epithelial alteration of transient receptor potential vanilloid channel type 1 (TRPV1) and cannabinoid receptors type 1 (CB1) and type 2 (CB2) in the human tongue. The study was performed on eight healthy controls and eight BMS patients. All patients underwent a 3-mm punch biopsy at the anterolateral aspect of the tongue close to the tip. TRPV1, CB1 and CB2 immunohistochemistry was carried out showing an altered expression of all receptors. In BMS patients there was increased TRPV1, decreased CB1 and increased CB2 expression in tongue epithelial cells also associated with a change in their distribution. It would appear that these receptors are related to BMS. These data could be useful for future characterization of BMS epithelial markers and therapy. Histol Histopathol 29, 523-533 (2014)es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and Histopathology, vol. 29, nº, 4, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/67961
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectBurning mouth syndromees
dc.subjectHuman tonguees
dc.subjectTransient receptor potential vanilloid channel type 1es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleEpithelial expression of vanilloid and cannabinoid receptors: a potential role in burning mouth syndrome pathogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 4 (2014)