Hyperlipidemia and kidney disease: Concepts derived from histopathology and cell biology of the glomerulus

Kamanna, V. S.; Roh, D. D.; Kirschenbaum, M. A.

Publication:
Hyperlipidemia and kidney disease: Concepts derived from histopathology and cell biology of the glomerulus

dc.contributor.author	Kamanna, V. S.
dc.contributor.author	Roh, D. D.
dc.contributor.author	Kirschenbaum, M. A.
dc.date.accessioned	2020-05-22T13:10:56Z
dc.date.available	2020-05-22T13:10:56Z
dc.date.issued	1998
dc.description.abstract	The association between hyperlipidemia and renal disease was noted by Virchow as earl y as the 19th ce ntury. Subseq ue ntl y, similar histopatho log ica l lipid depo siti o ns we re confirme d in diverse huma n a nd experimental renal diseases. Altho ugh, no studies have been established in man to suggest a causal re lationship between lipid s and the pathogenesis of rena l disease . compe llin g ev id e nce acc umul a te d in experimental animals suggests a direct role of lipids in the initiation and progression of glome rular disease. These studi es showed that cho lesterol-feed ing to various experimental animals induced the development of glomerul ar injury. Furthermore. the treatment of hype rlipidemic a nima ls with lipid lowering drugs prevented the deve lopment of glomenllosclerosis. In this article, we will rev iew recent advances made in understanding various aspects of lipid-mediated rena l injury inc ludin g bioc he mi ca l mec ha nisms of hype rlipidemia, a possible direct role of hyperlipidemi a in the pa th oge nesis o f ren a l disease, pathobiological acc umulation of lipids and lipoprote ins, biochemi cal and histological similarities between systemic atherosclerosis and glomerulosclerosis, and cellular processes invo lved in the development of glomerul ar disease. Furthermore, we will define cellular and mo lecul ar hypotheses that provide putative mechanisms by which hyperlipidemia a nd a theroge ni c lipo pro tei ns indu ce se ri es o f cy toregulatory peptide- med iated eve nts in vo lved in the development of glomerul ar disease.	es
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.citation	Histology and histopathology, Vol. 13, nº 1 (1998)
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/92542
dc.language	eng	es
dc.publisher	F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Hypercholesterolemia	es
dc.subject	Atherogenic lipoprote ins	es
dc.subject	Cytokines	es
dc.subject	Growth fractors	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Hyperlipidemia and kidney disease: Concepts derived from histopathology and cell biology of the glomerulus	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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