Publication: Ultrastructural study of ovine pulmonary pasteurellosis, involvement of neutrophils and macrophages
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Date
2001
Authors
Gázquez, A. ; Redondo, E. ; Martínez, S. ; Gómez, L.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Pasteurellosis is a common infectious disease
characterised by fibrinous pneumonia and involving
neutrophils and macrophages. This study aimed to
determine the timing and extent of the pathogenic
involvement of these cell elements in lesions induced in
experimentally-infected lambs.
A concentration of approximately 3 x 1 0 ~ba cterialml.
was inoculated into 30 two-month-old disease-free
Merino lambs. Five lambs were assigned to each of five
experimental batches, slaughtered on days 1, 3,7, 11 and
15 following intratracheal inoculation, and to one control
batch inoculated with a sterile solution. One control
animal was slaughtered at the same time as each
experimental batch.
More characteristic lesions occur in bronchioles,
peribronchial tissue and alveoli and are characterised by
fibrinous processes. From the start of the experiment,
epithelial-cell disruption and loss of microvilli were
apparent; cell debris, desquamate cells and bacterial
elements were observed in bronchiolar lumina,
embedded in a fibrillar granular material. Alveolar
structures displayed fewer neutrophils and macrophages,
containing phagocytic vacuoles. Laminar bodies were
apparent in type 11 pneumocytes. The interseptal area
contained similar cell types, as well as abundant edema.
In the course of the experiment, macrophage numbers
increased in al1 the areas involved, with signs of intense
phagocytic activity. The final phase of the experiment
was characterised by a mild interseptal infiltrate and by
clear alveolar lumina.
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