Publication: Effects of chronic ethanol administration on the serotonin-producing cells in rat gastric antral and duodenal mucosa
Loading...
Date
1993
Authors
Todorovic, V. ; Koko, V. ; Varagic, J. ; Lackovic, V. ; Vuzevski, V.D. ; Milin, J.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The present study describes our observations
on optical and ultrastructural features of serotonincontaining
cells in the rat antral and upper duodenal
mucosa, utilizing optic morphometric measurements in a
model of experimental chronic alcoholism of rat in
which nutrition was well controlled. Male Wistar rats
were given ethanol to provide 23 per cent of the total
calories, while starch replaced ethanol isocalorically in
controls. Twenty-five per cent of the calories were
provided by protein in both groups. Blood levels of
serotonin were significantly raised after chronic ethanol
feeding (0.05910.06 vs. 0.15910.012 pglml, p<0.01).
Decrease in the number of immunohistochemicallydetectable
serotonin-containing cells was found in the
pyloric gland mucosal area specimens of the chronically
ethanol-treated rats (68.915.2 vs 43.313.0; p<0.001).
The immunohistologically-evaluated number of the
same cells in the duodenal mucosa specimens was
significantly decreased by alcohol feeding. Although
total villi and crypt count per whole circular section, and
the number of crypts per villus were not significantly
changed either in control animals or in chronically
ethanol-fed rats, decreased number of these cells per whole circular section (289121.6 vs. 183f 10.5; p<O.OOI)
per villus (2.5210.14 vs. 1.2110.10; p<0.001) and per
crypts (0.97kO.08 vs. 0.7910.04; p<0.05) were reported
after alcohol consumption. In both control and
experimental rats the cells were predominantly found in
the basa1 half of the antropyloric mucosa. Alcohol did
not lead to any changes in normal distribution of the
duodenal serotonin-producing cells. The above
quantitative changes in serotonin-producing cells were
not accompanied by changes in their subcellular
appearance in stomach and duodenal mucosa of alcoholtreated
rat.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.