Molecular Segmentation of the Spinal Trigeminal Nucleus in the Adult Mouse Brain

García-Guillén, Isabel M.; Martínez-de-la-Torre, Margaret; Puelles, Luis; Aroca Tejedor,  Pilar; Marín San Leandro, Faustino

Publication:
Molecular Segmentation of the Spinal Trigeminal Nucleus in the Adult Mouse Brain

dc.contributor.author	García-Guillén, Isabel M.
dc.contributor.author	Martínez-de-la-Torre, Margaret
dc.contributor.author	Puelles, Luis
dc.contributor.author	Aroca Tejedor, Pilar
dc.contributor.author	Marín San Leandro, Faustino
dc.contributor.department	Anatomía Humana y Psicobiología
dc.date.accessioned	2023-11-15T09:23:32Z
dc.date.available	2023-11-15T09:23:32Z
dc.date.issued	2021-12-10
dc.description	© 2021. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published version of a Published Work that appeared in final form in Frontiers in Neuroanatomy. To access the final edited and published work see https://doi.org/10.3389/fnana.2021.785840	es
dc.description.abstract	The trigeminal column is a hindbrain structure formed by second order sensory neurons that receive afferences from trigeminal primary (ganglionic) nerve fibers. Classical studies subdivide it into the principal sensory trigeminal nucleus located next to the pontine nerve root, and the spinal trigeminal nucleus which in turn consists of oral, interpolar and caudal subnuclei. On the other hand, according to the prosomeric model, this column would be subdivided into segmental units derived from respective rhombomeres. Experimental studies have mapped the principal sensory trigeminal nucleus to pontine rhombomeres (r) r2-r3 in the mouse. The spinal trigeminal nucleus emerges as a plurisegmental formation covering several rhombomeres (r4 to r11 in mice) across pontine, retropontine and medullary hindbrain regions. In the present work we reexamined the issue of rhombomeric vs. classical subdivisions of this column. To this end, we analyzed its subdivisions in an AZIN2-lacZ transgenic mouse, known as a reference model for hindbrain topography, together with transgenic reporter lines for trigeminal fibers. We screened as well for genes differentially expressed along the axial dimension of this structure in the adult and juvenile mouse brain. This analysis yielded genes from multiple functional families that display transverse domains fitting the mentioned rhombomeric map. The spinal trigeminal nucleus thus represents a plurisegmental structure with a series of distinct neuromeric units having unique combinatorial molecular profiles.	es
dc.format	application/pdf	es
dc.format.extent	19	es
dc.identifier.citation	Frontiers in Neuroanatomy. Volume 15 - 2021 -15:785840.
dc.identifier.doi	10.3389/fnana.2021.785840
dc.identifier.issn	Electrónico: 1662-5129
dc.identifier.uri	http://hdl.handle.net/10201/135725
dc.language	eng	es
dc.publisher	Frontiers Media	es
dc.relation	This work was funded by a Seneca Foundation grant to LP (Autonomous Community of Murcia, Excellency Research contract, reference: 19904/GERM/15; 5672 Fundación Séneca; project name: Genoarchitectonic Brain Development and Applications to Neurodegenerative Diseases and Cancer). IG-G was the recipient of a predoctoral fellowship from the FPU program at the University of Murcia. Infrastructure support was provided by the University of Murcia and IMIB-Arrixaca Institute of Murcia.	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Hindbrain	es
dc.subject	Somatosensory system	es
dc.subject	Trigeminal system	es
dc.subject	Rhombomeres	es
dc.subject	Transcription factors	es
dc.subject	Tachykinins	es
dc.subject	Calcium-binding proteins	es
dc.subject	Fibronectin	es
dc.title	Molecular Segmentation of the Spinal Trigeminal Nucleus in the Adult Mouse Brain	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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relation.isAuthorOfPublication.latestForDiscovery	39981627-8a1e-4c85-b05b-af14ef212804