Publication: Expression of differentiation-related genes in colorectal cancer, possible implications for prognosis
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Date
1998
Authors
van Belzen, N. ; Dinjens, W.N.M. ; Eussen, B.H.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Although differentiation grade is an
important prognostic factor for colorectal tumors, its
usefulness is limited since its predictive value for tumor
behavior is not very significant. This might be related to
the subjective nature of histological assessment of
differentiation grade, which allows the distinction of
only three grades, and with limited reproducibility.
Characterization of the differentiation process at the
biochemical level may improve our understanding of
normal and malignant differentiation, and is expected to
provide molecular markers with higher discriminative
potential than histomorphology. Several studies have
compared gene expression in undifferentiated and
differentiated colon carcinoma c e l l s , and many
differentially expressed genes have been identified.
Some of these, including HLA class I, nucleophosmin,
adenylosuccinate lyase, a-tubulin, and a novel gene
designated Drgl, were found to be expressed at different
levels in neoplastic as compared to normal tissue. In this
review the rationale, implementation, and results of this
approach are discussed, as well as the characteristics of
two novel differentially expressed genes, ICTl
(previously named DS-1) and Drgl .
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