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Pga26 mediates filamentation and biofilm formation and is required for virulence in Candida albicans.

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dc.contributor.authorLaforet, Leslie
dc.contributor.authorMoreno, Inmaculada
dc.contributor.authorSánchez Fresneda, Ruth
dc.contributor.authorMartínez, José P.
dc.contributor.authorArgüelles, Juan Carlos
dc.contributor.authorGroot, Piet W.J. de
dc.contributor.authorValentín Gómez, Eulogio
dc.contributor.authorMartínez-Esparza Alvargonzález, María Concepción
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2024-07-03T07:49:13Z
dc.date.available2024-07-03T07:49:13Z
dc.date.issued2011-08
dc.description© 2011 Federation of European Microbiological Societies. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published version of a Published Work that appeared in final form in FEMS Yeast Research. To access the final edited and published work see https://doi.org/10.1111/j.1567-1364.2011.00727.x
dc.description.abstractThe Candida albicans gene PGA26 encodes a small cell wall protein and is upregulated during de novo wall synthesis in protoplasts. Disruption of PGA26 caused hypersensitivity to cell wall-perturbing compounds (Calcofluor white and Congo red) and to zymolyase, which degrades the cell wall β-1,3-glucan network. However, susceptibility to caspofungin, an inhibitor of β-1,3-glucan synthesis, was decreased. In addition, pga26Δ mutants show increased susceptibility to antifungals (fluconazol, posaconazol or amphotericin B) that target the plasma membrane and have altered sensitivities to environmental (heat, osmotic and oxidative) stresses. Except for a threefold increase in β-1,6-glucan and a slightly widened outer mannoprotein layer, the cell wall composition and structure was largely unaltered. Therefore, Pga26 is important for proper cell wall integrity, but does not seem to be directly involved in the synthesis of cell wall components. Deletion of PGA26 further leads to hyperfilamentation, increased biofilm formation and reduced virulence in a mouse model of disseminated candidiasis. We propose that deletion of PGA26 may cause an imbalance in the morphological switching ability of Candida, leading to attenuated dissemination and infection.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationFEMS Yeast Research, 2011, Vol. 11, Issue 5, pp. 389–397
dc.identifier.doihttps://doi.org/10.1111/j.1567-1364.2011.00727.x
dc.identifier.issnPrint: 1567-1356
dc.identifier.issnElectronic: 1567-1364
dc.identifier.urihttp://hdl.handle.net/10201/142822
dc.languageenges
dc.publisherBlackwell Publishing Ltd.es
dc.relationThis work was supported by the Spanish Ministry of Science and Technology (BFU2006-08684), University of Valencia (UV-AE-10-24011), Comunidad de Murcia (DGI, BIOBMC 06/01-0003) and a contract provided by Cespa S.A. TEM imaging was performed at the Servicio de Microscopía Electrónica S.C.S.I.E, University of Valencia.es
dc.relation.publisherversionhttps://academic.oup.com/femsyr/article/11/5/389/555369es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCandida albicanses
dc.subjectPGA26es
dc.subjectCell walles
dc.subjectBiofilmes
dc.subjectFilamentationes
dc.subjectIrulencees
dc.titlePga26 mediates filamentation and biofilm formation and is required for virulence in Candida albicans.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication79449fb4-f715-4255-a064-bfecc4b502de
relation.isAuthorOfPublication.latestForDiscovery79449fb4-f715-4255-a064-bfecc4b502de
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