Publication: Dying and regeneration of human tumor cells after heterotransplantation to athymic mice
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Date
1986
Authors
Köpf-Maler, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The histologic phenomena occurring
immediately after heterotransplantation of two human
colon adenocarcinomas to athymic mice have been studied.
The tumors differed with respect to velocity of growth and
passage age. Three phases were discernible in both cases.
(1) During the first phase, most inoculated tumor cells died.
(2) The second phase was characterized by removal of the
necrotic tumor cells by immigrated inflammatory cells and
by penetration of the connective tissue of host animals from
peripheral into central areas of the implants. The first
mitoses occurred within tumor cells in close proximity to
these connective tissue septa. (3) During the third phase,
signs of regeneration and proliferation of tumor cells
resulted in the macroscopic enlargement of xenografts. Only
in this phase, the typical histologic characteristics of the
tumors were formed.
These observations point to the host connective tissue
invading into implants to be of great importance for the
stimulation of tumor cell proliferation and, therefore, for
the growth of xenografts. Thus, successful
heterotransplantation is obviously based on mutual events
between the transplanted tumor cells and host connective tissue
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